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About Mission and Outline Background Activities For Community Message from Executive Director Toward the Development of Personalized Healthcare through the Promotion of Industry-Academia Collaboration Organization and Members Department of Community Medical Supports Department of Preventive Medicine and Epidemiology Department of Biobank Department of Integrative Genomics Department of Health Record Informatics Department of Education and Training Department of Public Relations and Planning General Affairs and Planning Sector Cohort Studies Sector Integrated Biobank Sector Integrated Omics Sector Group of Planning Group of Public Relations Group of Education and Training Group of Return of Genomic Results Center for Promotion of Cohort Studies Center for Health Survey Promotion Group of Brain Imaging and Research Group of Biobank Center for Biobank Utilization and Academia-Industry Partnership Group of Integrated Database Systems Group of Information Management for Genome-Cohort Study Group of Privacy Controls Group of Sequencing Group of Microarray-based Genotyping Group of Metabolomics Group of Metagenomics and Microbiome Group of Omics Data Analysis Center for Genome-Wide Association Study Office of Nihonbashi Branch Operation Center for Genome Platform Projects Policy Site Policy Social Media Policy Research Cohort Study and Biobank Community-Based Cohort Study (TMM CommCohort Study) Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) Integrative Genomics Publications Facilities and Equipment Researchers Specimen and Data Collection Ethical Issues ToMMo's Library News Timeline sitemap links access & contact JAPANESE Large Small A A Top ResearchNew article reporting the design and results of the Brain-MRI Study was published in Journal of the Japan Medical Association News Timeline all News Events Research Monthly archives 2024, April 2024, February 2024, January 2023, November 2023, October 2023, September 2023, August 2023, July 2023, June 2023, May 2023, April 2023, March 2023, January 2022, December 2022, November 2022, October 2022, September 2022, July 2022, May 2022, April 2022, January 2021, December 2021, November 2021, September 2021, August 2021, July 2021, June 2021, March 2021, January 2020, November 2020, October 2020, September 2020, August 2020, July 2020, June 2020, April 2020, March 2020, February 2020, January 2019, December 2019, November 2019, September 2019, August 2019, July 2019, May 2019, April 2019, March 2019, February 2019, January 2018, December 2018, November 2018, October 2018, September 2018, August 2018, July 2018, June 2018, May 2018, March 2018, February 2018, January 2017, December 2017, November 2017, October 2017, September 2017, August 2017, July 2017, June 2017, May 2017, March 2017, February 2017, January 2016, December 2016, November 2016, October 2016, September 2016, August 2016, July 2016, June 2016, May 2016, April 2016, March 2016, February 2016, January 2015, December 2015, November 2015, October 2015, September 2015, August 2015, July 2015, June 2015, May 2015, April 2015, March 2015, February 2015, January 2014, November 2014, October 2014, August 2014, July 2014, April 2014, March 2014, February 2014, January 2013, November 2013, August 2013, July 2013, June 2013, May 2013, April 2013, February 2013, January 2012, December 2012, November 2012, October 2012, September 2012, April 2012, March 2012, February New article reporting the design and results of the Brain-MRI Study was published in Journal of the Japan Medical Association Research: 2023/07/19 New article about the Brain-MRI Study has been published in the Journal of the Japan Medical Association. The article describes the background, purpose, design, data management and reports on the results of the study. In recent years, magnetic resonance imaging (MRI) has been used to study the early detection and risk assessment of disease. Amongst these, large-scale prospective cohort studies have been particularly effective in allowing us to understand how cognitive decline and mental illness progress on a deeper level. In 2014, we started the TMM Brain-MRI Study as part of the TMM Community-based Cohort Study (TMM CommCohort Study) and the TMM Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study). The study looked at how the brain changes with age by examining data from the same individual over time. By 2019, brain MRI images and test results for cognitive assessments and psychological status from more than 12,000 people ranging from young to old were collected. The ongoing study is now at the second survey stage, with data from approximately 60% of the total participants collected. The goal of this study is to create a database of each individual’s brain by analyzing MRI data, cognitive assessments, psychological profiles, and data from the main cohort study. This includes those such as health status, lifestyle, and body biomarkers (indicators of body information) to be able to analyze normal aging, as well as the progression of diseases. The initial analysis showed that 1)the total gray matter volume as well as the left and right hippocampal volumes analyzed indicated that the brain atrophies as we age; and 2) approximately 16% of the subjects in the study had a possibility of cognitive decline (concluded from the administration of the Mini-Mental State Examination (MMSE), a test of cognitive function, to a total of 3,610 people aged 65 or older). This study is the first large-scale study in Japan on brain structure and related characteristics during the healthy aging process, a situation that is rare and valuable worldwide. “The Brain-MRI Study is an extremely important addition to the Tohoku Medical Megabank Project's dataset,” said Professor Shunji Mugikura, a neuroradiologist and group leader of the Brain Imaging and Research at the ToMMo. “We are already leveraging this unique dataset to contribute novel insights to the global understanding of these very important age-related changes. Historically, such data was almost entirely obtained in the Western countries, so the Brain-MRI Study will provide knowledge of such factors about the Japanese population for the first time.” Dr. Makiko Taira, a neurologist and deputy group leader of the research, as well as being the first author of the publication said, “By coupling brain structure data and the massive genomic and biomarker data acquired from the TMM CommCohort Study and TMM BirThree Cohort Study, the Brain-MRI Study is enabling unique analyses of genetic factors impacting the maintenance of brain integrity in normal aging and its loss in late life neurodegenerative diseases such as Alzheimer’s disease.” Publication Details Title: Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background Authors: Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, Tomo Saito, Tomohiro Nakamura, Hideyasu Kiyomoto, Tadao Kobayashi, Soichi Ogishima, Fuji Nagami, Akira Uruno, Ritsuko Shimizu, Tomoko Kobayashi, Jun Yasuda, Shigeo Kure, Miyuki Sakurai, Ikuko N. Motoike, Kazuki Kumada, Naoki Nakaya, Taku Obara, Kentaro Oba, Atsushi Sekiguchi, Benjamin Thyreau, Tatsushi Mutoh, Yuji Takano, Mitsunari Abe, Norihide Maikusa, Yasuko Tatewaki, Yasuyuki Taki, Nobuo Yaegashi, Hiroaki Tomita, Kengo Kinoshita, Shinichi Kuriyama, Nobuo Fuse and Masayuki Yamamoto Journal: Journal of the Japan Medical Association Published date: July 14, 2023 DOI: 10.31662/jmaj.2022-0220 News Timeline Tweet About Mission and Outline Background Activities For Community Message from Executive Director Organization and Members Policy Research Cohort Study and Biobank Integrative Genomics Publications Facilities and Equipment Researchers Ethical Issues Specimen &＃038; Data Collection ToMMo's Library News Timeline access & contact sitemap links JAPANESE Large Small A A Copyright(C) Tohoku University Tohoku Medical Megabank Organization All Rights Reserved. sitemap access & contact About Research Ethical Issues Specimen &＃038; Data Collection ToMMo's Library News Timeline access & contact sitemap links Japanese